Naiman Sag of Kailu Basin has developed unique trona deposit, which is paragenetically associated with salt and crude oil. Based on the data of seismic, logging data, drilling core laboratory analysis, the lithology assemblage, ore characteristics, deposit features and distribution patterns of the trona deposit in Cretaceous Yixian Formation were clarified. Meanwhile, the genesis and patterns of the deposit were investigated in terms of paleostructure, paleoclimate, sources of ore-forming materials, and their coupling relationships. The research results indicate that: (1) The Yixian Formation deposit of Cretaceous in Naiman Sag is characterized by deep burial, steep dip, fault development, thin individual layers and numerous interbeds. Ore body shape is approximately elliptical, with a north-south distribution direction and a lenticular distribution pattern featuring thickened centers and thinning edges. Two sedimentary sequences are developed: A soda-lake type sequence (mudstone-dolomite → trona → mudstone) dominates the deposit margins, while a saline-lake type sequence (mudstone-dolomite → trona → halite → trona → mudstone) prevails in the central zone. On the plane, trona-saline trona-salt distribute in an annular pattern. (2) The deposits are generally oil-bearing. Within mudstone layers, crude oil occurs in intergranular pores of fine clastics, inter-crystalline pores of clay minerals, fractures, and kerogen. In trona and salt layers, hydrocarbons primarily reside in mineral inter-crystalline pores and fractures, cleavage fractures, inclusions, and lattice defects. (3) The trona deposit in the study area is a ternary coupled mineral model of “paleogeomorphology-paleoclimate-volcanic activity”, the deposition of Yixian Formation constituted a closed lacustrine basin. Sodium ions (Na⁺) were continuously supplied to the basin by sodium-rich andesitic rocks in the periphery. The decomposition of organic-rich mudstone produces considerable CO2, which increases the concentration of CO2 in brine. The frequent volcanic activities during the Yanshan period led to the upwelling of deep-seated hydrothermal fluids and mantle-derived gas through faults, providing a large amount of CO2 and Na+ -rich hydrothermal fluid. A persistent arid climate towards the end of Yixian Formation resulted in extreme concentration of the lake water, reaching saturation and precipitating trona or halite. Subsequent diagenesis formed the present trona deposit.