On the basis of sedimentary facies of single well, seimic data, as well as surface outcrop data，core observation，cutting logging and thin section analysis, the sedimentary facies in eastern Tarim Basin are defined, including abyssal facie, bathyal-contourite drift facies, near-shore deposits and carbonate platform. Several sub-facies and micro-facies are also recognized. Based on analysis of sedimentary microfacies, the sedimentary models, distribution and evolution in Early Cambrian-Middle Ordovician are analyzed. It is believed that plateau- basin model mainly developed in Early Cambrian in the east, and it is more obvious in Middle-Late Cambrian. Until Early-Middle Ordovician, the sedimentary facies in the study area is of typical trisection units, which are deep water aulacogen in middle part, carbonate platform and slope facies in the west and east. At the edge zone of platform and deep sea basin, reef flat reservoir developed, which is favorable for reservoir development. There also developed many types of diagenesis, and the destructive diagenesis is dominated one.