Based on the high resolution sequence stratigraphy and the seismic reservoir prediction techniques, a method of the lithological reservoirs exploration is proposed and then applied to Gaoliu area. The divided solution of sequence and the sequence stratigraphical framework are established by the study of high-resolution sequence stratigraphy based on high level cycle as reference level. The Dongying Formation is divided into one long-term level cycle and four medium-term level cycles. Using the seismic reservoir inversion technique which is constrained by the high-resolution sequence stratigraphic framework, twenty eight individual sand bodies in the four sequences are identified, which provides favorable evidence for the lithological reservoir exploration.