Based on the current status of the development in TZ422CⅢ oil group，the residual oil distribution after water flooding was investigated qualitatively and quantitatively using fine reservoir numerical simulation of E100 main module. According to the sedimentary facies map, considering the formation heterogeneity and sedimentary facies distribution, three deferent types of well network regulation schemes are designed. The result indicates that the well pattern which the vertical well and the horizontal well unify is used in CⅢ oil group. The best injection-production pattern of 18 wells with 4 new wells, 14 old wells. The preferred scheme is simulated to 2025, the final recovery efficiency is 46.13%, and the composite water cut is 89.06%.