In the development process of Chang 4+5 reservoir in Geng 43 well field in Puziwan area, there exist many problems such as rapid decline of deliverability in some wells, serious flooding, imperfect flooding pattern and non-well network control in local. In order to control the production decline effectively and improve flooding network, the dynamic analysis and numerical simulation study are carried out, and it is concluded that comprehensive regulated objects are remaining oil enrichment area and layer system. So the relevant adjustments are conducted to development layers and well pattern, and the optimum programis put forward: reperforating and plugging holes in the areas where has a higher movable remaining reserves or thicker effective pay thickness in some wells; converting low-yield and high water cut oil wells to injection wells; drilling infillers in the remaining oil enrichment area. The forecast result of the program shows that oil recovery increases remarkably under the optimum program.