In order to solve the problems of large increase of water-cut and increasingly decline of horizontal well production in multilayer edge water reservoir in Sudan, the reservoir is studied by integrate multi-discipline knowledge, and the development performance of horizontal well in various water cut stage is evaluated by using dimension less oil rate and dimensionless cumulative production and monthly incremental ratio of water cut. The results show that horizontal well is the essential technology that can stabilize production and control water cut in high water cut stage of multilayer edge water reservoir, Sudan. The well location, produced fluid intension and reservoir heterogeneity are the major controlling factors for water cut increasing, and the well location, produced fluid intension, reservoir pressure maintenance and formation protection situation are the major controlling factors for production decline. The development strategy is to strengthen horizontal well optimization design in early stage, and lift liquid and water shutoff to stabilize oil production and control water cut, inject water in due time to maintain reservoir pressure and strengthen formation protection in mid-later stage, in order to increase individual productivity and improve the development performance ofmultilayer edge reservoir.