Natural gas reserve-production ratio is a key index that describes the relationship between production scale and explored reserves. Accurate calculation of natural gas reserve-production ratio has important guiding significance for ensuring natural gas reasonable development and making national long-term strategy objectives. The production characteristics in the gas production rising stage, stable stage and decline stage were analyzed. Based on the relationship equations of production rising rate, recoverable reserve displacement rate and production decline rate, the calculation methods of natural gas reserve-production ratio in three different development stages were derived. At the same time, considered the relationship between recoverable reserve recovery percentage and reserve-production ratio in natural gas development, the relationship equations between recovery percentage and reserve-production ratio, reserves displacement rate, production rising rate（or production decline rate） were derived. The study result indicates that natural gas reserveproduction ratio shows obvious downtrend in the gas production rising stage, holds relatively stable in stable stage, and begins to descend smoothly in decline stage. The case analysis shows that this new method is reliable and practical for calculating natural gas reserve-production ratio in different development stages.