Single well condensate gas huff and puff can improve oilfield recovery ratio greatly, so the injection-production parameters optimization in single well condensate gas huff and puff has important production guiding significance. Based on the study of the effect of single well condensate gas puff and huff in reservoir B, this paper established the compositional simulation model, and analyzed the influencing factors to single well condensate gas huff and puff, including condensate gas cycle injection volume, injection rate, well shut-in time and production rate. The injectionproduction parameters of single well condensate gas huff and puffwere optimized with the orthogonal experiment design method. The optimized injection-production parameters are as the following: the injection volume is 283.2×10⁴ m³, injection rate is 11.3×10⁴m³/d, well shut-in time is 10d and production rate is 1 590 m³/d.