It is difficult for the field to achieve the CO₂ miscible flooding efficiency of indoor experiments which could reach more than 90%. Recovery factor is limited mainly by several aspects, namely, CO₂ viscous fingering, gravity overlap and reservoir heterogeneity, which exert negative influence on CO₂ sweep efficiency. On the other hand, gas channeling aggravates gradually and development conflicts intensify continuously at the later stage of production. This paper analyzed development effect of CO₂ flooding, regarding layer series of development, injection-production structure, way of injection and injection profile, moreover, proposed technologies of strata subdivision, injection in the top, water alternating gas（WAG）, polymer profile control and CO₂+foam flooding. Good response has been observed after the onsite implementation. Reservoir overall gas-oil ratio decreased from 2 733.1 m³/m³ to 63.84  m³/m³, and daily oil production increased from 30.72 t（before gas injection） to 81.68 t（after gas injection）. Generally, this anti-gas channeling comprehensive technology is of great significance for similar reservoir scenario design and gas channeling prevention.